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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TBX5
All Species:
30.91
Human Site:
S346
Identified Species:
56.67
UniProt:
Q99593
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99593
NP_000183.2
518
57711
S346
K
K
P
Y
M
E
T
S
P
S
E
E
D
S
F
Chimpanzee
Pan troglodytes
XP_509400
518
57702
S346
K
K
P
Y
M
E
T
S
P
S
E
E
D
S
F
Rhesus Macaque
Macaca mulatta
XP_001111737
518
57694
S346
K
K
P
Y
M
E
T
S
P
S
E
E
D
S
F
Dog
Lupus familis
XP_548568
518
57556
S346
K
K
P
Y
M
E
T
S
P
S
E
E
D
P
F
Cat
Felis silvestris
Mouse
Mus musculus
P70326
518
57813
S346
K
K
P
Y
M
E
T
S
P
S
E
E
D
T
F
Rat
Rattus norvegicus
Q5I2P1
517
57726
S345
K
K
P
Y
M
E
T
S
P
S
E
E
D
T
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509097
536
59706
P362
D
H
Y
F
R
S
P
P
P
Y
D
Q
Q
M
L
Chicken
Gallus gallus
Q9PWE8
521
58384
S346
K
K
P
Y
M
E
T
S
P
A
E
E
D
P
F
Frog
Xenopus laevis
Q9W7C2
519
58062
S346
K
K
P
Y
M
D
T
S
P
S
E
E
D
P
F
Zebra Danio
Brachydanio rerio
Q9IAK8
492
55218
I321
H
T
Q
D
Y
H
C
I
K
R
K
V
E
D
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24432
972
102538
P676
R
P
T
S
T
G
S
P
K
E
A
V
G
A
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q19691
423
46979
K252
G
A
G
K
R
E
K
K
R
Q
L
H
R
M
N
Sea Urchin
Strong. purpuratus
XP_797010
645
70075
P437
T
G
S
S
M
G
Q
P
K
R
R
L
S
G
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.6
96.5
N.A.
96.1
95.7
N.A.
53.1
88.4
79.1
70
N.A.
22
N.A.
32.8
31.6
Protein Similarity:
100
99.8
99.8
98.2
N.A.
97.8
98
N.A.
63.6
94.4
85.7
78.9
N.A.
32.7
N.A.
48.2
43.8
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
6.6
86.6
86.6
0
N.A.
0
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
26.6
93.3
93.3
13.3
N.A.
20
N.A.
6.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
0
8
8
0
0
8
8
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
8
0
8
0
0
0
0
8
0
62
8
0
% D
% Glu:
0
0
0
0
0
62
0
0
0
8
62
62
8
0
8
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
62
% F
% Gly:
8
8
8
0
0
16
0
0
0
0
0
0
8
8
0
% G
% His:
8
8
0
0
0
8
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
62
62
0
8
0
0
8
8
24
0
8
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
8
% L
% Met:
0
0
0
0
70
0
0
0
0
0
0
0
0
16
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% N
% Pro:
0
8
62
0
0
0
8
24
70
0
0
0
0
24
0
% P
% Gln:
0
0
8
0
0
0
8
0
0
8
0
8
8
0
0
% Q
% Arg:
8
0
0
0
16
0
0
0
8
16
8
0
8
0
0
% R
% Ser:
0
0
8
16
0
8
8
62
0
54
0
0
8
24
8
% S
% Thr:
8
8
8
0
8
0
62
0
0
0
0
0
0
16
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
16
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
62
8
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _